Curriculum Vitae

Personal Details

Education

Awards

Employment

Publications

1. Furness, J.B., Bornstein, J.C., Kunze, W.A.A., Bertrand, P.P., Kelly, H. & Thomas, E.A., (1996), Experimental basis for realistic large scale computer simulation of the enteric nervous system. Clin. Exp. Pharm. Physiol. 23:786-792 (Abstract)
2. Clerc N, Furness JB, Kunze WAA, Thomas EA, Bertrand PP.: Long Term Effects of Synaptic Activation at Low Frequency on Enteric Neurons Neuroscience. (1999) 90(1):279-289 (Abstract, Full text)
3. Thomas EA, Bertrand PP, Bornstein JB: Genesis and role of coordinated firing in a feedforward network - A model study. Neuroscience. (1999) 93(4):1525-1537 (Abstract, Full text)
4. Bertrand PP, Thomas EA, Kunze WAA, Bornstein JC: A simple mathematical model of second messenger mediated slow excitatory post-synaptic potentials. Journal of Computational Neuroscience. (2000) 8(2):127-142 (Abstract, Full text)
5. Thomas EA: A parallel algorithm for simulation of large neural networks. Journal of Neuroscience Methods. (2000) 98(2):123-134 (Abstract, Full text)
6. Thomas EA, Bertrand PP, Bornstein JB: A computer simulation of recurrent, excitatory networks of sensory neurons of the gut in guinea-pig. Neuroscience Letters (2000) 287(2):137-140. (Abstract, Full text)
7. Thomas EA, Bornstein JB: Inhibitory cotransmission or after hyperolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience (2003) 120(2):333-351 (Abstract, Full text)
8. Thomas EA, Sjövall H, Bornstein JB: A computational model of the migrating motor complex in the small intestine. Am J Physiol Gastrointest Liver Physiol (2004) 286:G564-G572 (Abstract, Full text)
9. Gwynne RM, Thomas EA, Goh M, Sjövall H, Bornstein JC: Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum. J Physiol (Lond) 2004 556: 557-569 (Abstract, Full text)
10. Boyer CP, Galicki KS, Kollár J, Thomas EA: Einstein Metrics on Exotic Spheres in Dimensions 7,11 and 15. Experimental Mathematics 14:59-64(2005) (Abstract, Full text)
11. Bertrand PP, Thomas EA: Multiple Levels of Sensory Integration in the Intrinsic Sensory Neurons of the Enteric Nervous System (Brief review) Clin Exp Pharmacol Physiol (2004) 31: 745-755 (Abstract, Full text)
12. Chambers JD, Bornstein JC, Sjövall H, Thomas EA. Recurrent networks of submucous neurons controlling intestinal secretion: a modelling study. Am J Physiol Gastrointest Liver Physiol (2005) 288: G887-G896. (Abstract, Full text)
13. Kordasti S, Sapnara M, Thomas EA, Lindstrom E, Forsman M, Bornstein JC, Sjövall H. Effects of cholera toxin on the potential difference and motor responses induced by distension in rat proximal small intestine, in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 290:G948-58. (Abstract, Full text)
14. Davies PJ, Thomas EA, Bornstein JC. Different types of potassium channels underlie the long afterhyperpolarization in guinea-pig sympathetic and enteric neurons. Auton Neurosci. 2006 124:26-30. (Abstract, Full text)
15. Thomas EA(*), Xu R(*), Jenkins M, Gazina EV, Chiu C, Heron SE, Mulley JC, Scheffer IE, Berkovic SF, Petrou S. A childhood epilepsy mutation reveals a role for developmentally regulated splicing of a sodium channel. Mol Cell Neurosci 2007 35:292-301 (*) First 2 authors contributed equally. (Abstract, Full text)
16. Larsson MH, Simrén M, Thomas EA, Bornstein JC, Lindström E, Sjövall H. Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome. Neurogastroenterol Motil. (2007) 19:812-20 (Abstract, Full text)
17. Thomas EA, Xu R, Petrou S. Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience 2007 147:1034-46 (Abstract, Full text)
18. Xu R, Thomas EA, Gazina EV, Richards KL, Quick M, Wallace RH, Harkin LA, Heron SE, Berkovic SF, Scheffer IE, Mulley JC, Petrou S. GEFS+ associated SCN1B mutations cause loss of function. Neuroscience 2007 148:164-174 (Abstract, Full text)
19. Larsson MH, Sapnara M, Thomas EA, Bornstein JC, Lindström E, Svensson DJ, Sjövall H. harmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo. Am J Physiol Gastrointest Liver Physiol (2008) 294:G165-73 (Abstract, Full text)
20. Chambers JD, Bornstein JC, Thomas EA.Insights into mechanisms of intestinal segmentation in guinea pigs: a combined computational modeling and in vitro study. Am J Physiol Gastrointest Liver Physiol (2008) 295:G534-41 (Abstract, Full text)
21. Thomas EA, Petrou S. The case for realistic modelling in understanding seizures. Expert Rev Neurother. (2008) In press.
22. Thomas EA, Hawkins RJ, Richards KL, Xu R, Gazina EV, Petrou S. Heat opens axon initial segment sodium channels: A febrile seizure mechanism? Annals of Neurology, (2009) In press, 10.1002/ana.21712
23. Thomas EA, Reid CA, Petrou S. Mossy fibre sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia, (2009) In press.
24. Bajor A, Ung K-A, Öhman L, Simren M, Thomas EA, Bornstein JC, Sjövall H. Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurons in patients with idiopathic bile acid malabsorption. Acta Physiol, (2009) Apr 27. [Epub ahead of print]. (Abstract)
25. Thomas EA, Reid CA, Petrou S. Modeling predicts that epilepsy may be caused by very small functional changes in ion channels. Arch Neurol, In press

Thomas EA, Bertrand PP, Kunze WAA, Bornstein JC, Furness, J.B., (1996), A computer model of the slow excitatory post-synaptic potential in enteric neurons. Proceedings of the Australian Physiological and Pharmacological Society, 27(2):171P.

Thomas EA, Bertrand PP, Kunze WAA, Bornstein JC, Furness JB, (1997), A simple mathematical model of the slow EPSP for use in large network simulations, Journal of the Autonomic Nervous System, 64(2-3):138.

Thomas EA, Bornstein JC (1999), A computer model of summation of neural inputs in smooth muscle, Proceedings of the Australian Neuroscience Society 10:138.

Thomas EA, Bornstein JC (2000), A computer simulation of recurrent networks of gut sensory neurons, Proceedings of the Australian Neuroscience Society 11:158

Thomas EA, Bornstein JC (2001), Computer simulation indicates no role for inhibitory post synaptic potentials in recurrent networks of enteric sensory neurons, Proceedings of the Australian Neuroscience Society 12:64

Thomas EA, Sjövall H, Bornstein JC, (2003) A computational model of the migrating motor complex of the small intestine, International Society for Autonomic Neuroscience (ISAN)

Thomas EA, Sjövall H, Bornstein JC,(2003) Oscillations in networks of AH neurons: a driver of intestinal motor patterns? Enteric nervous system satellite meeting to ISAN 2003

Thomas EA, Xu RW, Petrou S. Computational analysis of the R85C and R85H epilepsy mutations in Na channel beta1 subunits. Society for Neuroscience (2006)

Hawkins RJ, Thomas EA, Xu RW, Sergeyev O, Petrou S. Temperature sensitivity of an epilepsy causing sodium channel beta1 subunit mutation. Society for Neuroscience (2006)

Grants and fellowships

Bornstein JC, Thomas EA, Parry LJ, Bertrand PP. How nutrients and other gut contents produce the gut movements essential to the digestion of food and excretion of waste. NHMRC Project grant. $1,092,500 (2009-2013)

H.Sjövall, M.Simrén , J.Bornstein, E.Thomas, M.Forsman. Integration between intestinal motility and secretion Swedish Scientific Council. (2003-2005) $545000.

E.Thomas. Dynamics of slow synaptic transmission University of Melbourne early career researcher award. (2003) $38846.

E.Thomas. Analysis of mouse models of human familial epilepsies, NHMRC Peter Doherty Fellowship. (2004-2007) $240000

Erdös number: 3