Curriculum
Vitae
Personal Details
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Full Name:
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Evan Alexander Thomas
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Mailing Address:
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Howard Florey Institute
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c/o University of Melbourne
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Parkville, Victoria, 3010
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AUSTRALIA
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Work phone:
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(61) (3) 8344 1954
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Fax:
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(61) (3) 9347 0446
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Email:
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evan@evan-thomas.net
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Birth date:
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29 April 1961
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Citizenship:
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Australian
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Education
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1979 - 1982
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B.Sc(Hons) in physics, University of Melbourne. First class
honours
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1983 - 1985
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MA in physics, State University of New York at Stony Brook,
USA.
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1995 - 1997
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M.App.Sc(IT) in computer science, RMIT University, Melbourne
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1997 - 2001
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PhD -
Topic: Mathematical and computer modelling of the enteric
nervous system
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Awards
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1978
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Senior Scholarship
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1981
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Wyselaskie Scholarship in Natural Science
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1982
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Dixson Research Scholarship in Physics (shared)
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1982
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Professor Kernot Scholarship (shared)
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Employment
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1987 - 1995
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National Australia Bank. Various systems programming roles.
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1995 - 2002
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Department of Physiology, University of Melbourne. Employed as
a programmer developing software for realistic neural modeling,
specifically in the enteric nervous system.
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2003
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Department of Physiology, University of
Melbourne. Senior research officer in the
Enteric Neuroscience Lab building and
exploring models of intestinal motor pattern generation.
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2004 - present
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Howard Florey Institute, University of
Melbourne. Senior research officer in the
Ion Channels and Diseases Group building and
exploring models of ideopathic generalised epilepsy.
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Publications
- Furness, J.B., Bornstein, J.C., Kunze, W.A.A., Bertrand, P.P.,
Kelly, H. & Thomas, E.A., (1996), Experimental basis for
realistic large scale computer simulation of the enteric nervous
system. Clin. Exp. Pharm. Physiol. 23:786-792 (Abstract)
- Clerc N, Furness JB, Kunze WAA, Thomas EA, Bertrand
PP.: Long Term Effects of Synaptic Activation at Low Frequency on
Enteric Neurons Neuroscience. (1999) 90(1):279-289 (Abstract, Full text)
- Thomas EA, Bertrand PP, Bornstein JB: Genesis and role of
coordinated firing in a feedforward network - A model study.
Neuroscience. (1999) 93(4):1525-1537 (Abstract,
Full
text)
- Bertrand PP, Thomas EA, Kunze WAA, Bornstein JC: A
simple mathematical model of second messenger mediated slow
excitatory post-synaptic potentials. Journal of Computational
Neuroscience. (2000) 8(2):127-142 (Abstract,
Full
text)
- Thomas EA: A parallel algorithm for simulation of large neural
networks. Journal of Neuroscience Methods. (2000) 98(2):123-134
(Abstract,
Full
text)
- Thomas EA, Bertrand PP, Bornstein JB: A computer
simulation of recurrent, excitatory networks of sensory neurons of
the gut in guinea-pig. Neuroscience Letters (2000) 287(2):137-140. (Abstract,
Full
text)
- Thomas EA, Bornstein JB: Inhibitory cotransmission or after hyperolarizing potentials
can regulate firing in recurrent networks with excitatory
metabotropic transmission. Neuroscience (2003) 120(2):333-351 (Abstract,
Full
text)
- Thomas EA, Sjövall H, Bornstein JB:
A computational model of the migrating motor complex in the small intestine.
Am J Physiol Gastrointest Liver Physiol (2004) 286:G564-G572
(Abstract,
Full
text)
- Gwynne RM, Thomas EA, Goh M, Sjövall H,
Bornstein JC:
Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum.
J Physiol (Lond) 2004 556: 557-569
(Abstract,
Full
text)
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Boyer CP, Galicki KS, Kollár J, Thomas EA:
Einstein Metrics on Exotic Spheres in Dimensions 7,11 and 15.
Experimental Mathematics 14:59-64(2005)
(Abstract,
Full
text)
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Bertrand PP, Thomas EA: Multiple Levels of Sensory Integration in the
Intrinsic Sensory Neurons of the Enteric Nervous System (Brief review)
Clin Exp Pharmacol Physiol (2004) 31: 745-755
(Abstract, Full text)
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Chambers JD, Bornstein JC, Sjövall H, Thomas EA. Recurrent
networks of submucous neurons controlling intestinal secretion: a
modelling study. Am J Physiol Gastrointest Liver Physiol (2005)
288: G887-G896.
(Abstract, Full text)
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Kordasti S, Sapnara M, Thomas EA, Lindstrom E, Forsman M, Bornstein
JC, Sjövall H.
Effects of cholera toxin on the potential difference and motor
responses induced by distension in rat proximal small intestine, in
vivo. Am J Physiol Gastrointest Liver Physiol. 2006 290:G948-58.
(Abstract,
Full text)
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Davies PJ, Thomas EA, Bornstein JC. Different types of potassium
channels underlie the long afterhyperpolarization in guinea-pig
sympathetic and enteric neurons. Auton Neurosci. 2006 124:26-30. (Abstract,
Full text)
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Thomas EA(*), Xu R(*), Jenkins M, Gazina EV, Chiu C, Heron SE, Mulley
JC, Scheffer IE, Berkovic SF, Petrou S. A childhood epilepsy mutation
reveals a role for developmentally regulated splicing of a sodium
channel. Mol Cell Neurosci 2007 35:292-301 (*) First 2 authors
contributed equally. (Abstract, Full text)
- Larsson MH, Simrén M, Thomas EA, Bornstein JC, Lindström E,
Sjövall H. Elevated motility-related transmucosal potential
difference in the upper small intestine in the irritable bowel
syndrome. Neurogastroenterol Motil. (2007) 19:812-20
(Abstract, Full text)
- Thomas EA, Xu R, Petrou S. Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience 2007 147:1034-46
(Abstract, Full
text)
- Xu R, Thomas EA, Gazina EV, Richards KL, Quick M, Wallace RH,
Harkin LA, Heron SE, Berkovic SF, Scheffer IE, Mulley JC, Petrou
S. GEFS+ associated SCN1B mutations cause loss of
function. Neuroscience 2007 148:164-174 (Abstract, Full text)
- Larsson MH, Sapnara M, Thomas EA, Bornstein JC, Lindström E, Svensson DJ,
Sjövall H. harmacological analysis of components of the change in
transmural potential difference evoked by distension of rat proximal small
intestine in vivo. Am J Physiol Gastrointest Liver Physiol (2008) 294:G165-73
(Abstract, Full text)
- Chambers JD, Bornstein JC, Thomas EA.Insights into mechanisms of
intestinal segmentation in guinea pigs: a combined computational modeling and
in vitro study.
Am J Physiol Gastrointest Liver Physiol (2008) 295:G534-41
(Abstract, Full text)
- Thomas EA, Petrou S. The case for realistic modelling in understanding
seizures. Expert Rev Neurother. (2008) In press.
First author abstracts
Thomas EA, Bertrand PP, Kunze WAA, Bornstein JC,
Furness, J.B., (1996), A computer model of the slow excitatory
post-synaptic potential in enteric neurons. Proceedings of the
Australian Physiological and Pharmacological Society, 27(2):171P.
Thomas EA, Bertrand PP, Kunze WAA, Bornstein JC,
Furness JB, (1997), A simple mathematical model of the slow EPSP
for use in large network simulations, Journal of the Autonomic
Nervous System, 64(2-3):138.
Thomas EA, Bornstein JC (1999), A computer model of
summation of neural inputs in smooth muscle, Proceedings of the
Australian Neuroscience Society 10:138.
Thomas EA, Bornstein JC (2000), A computer simulation of
recurrent networks of gut sensory neurons, Proceedings of the
Australian Neuroscience Society 11:158
Thomas EA, Bornstein JC (2001), Computer simulation indicates
no role for inhibitory post synaptic potentials in recurrent networks
of enteric sensory neurons, Proceedings of the Australian Neuroscience
Society 12:64
Thomas EA, Sjövall H, Bornstein JC, (2003) A computational model of the
migrating motor complex of the small intestine, International Society
for Autonomic Neuroscience (ISAN)
Thomas EA, Sjövall H, Bornstein JC,(2003) Oscillations in networks of AH
neurons: a driver of intestinal motor patterns? Enteric nervous system
satellite meeting to ISAN 2003
Thomas EA, Xu RW, Petrou S. Computational analysis of the R85C and
R85H epilepsy mutations in Na channel beta1 subunits. Society for
Neuroscience (2006)
Hawkins RJ, Thomas EA, Xu RW, Sergeyev O, Petrou S. Temperature
sensitivity of an epilepsy causing sodium channel beta1 subunit
mutation. Society for Neuroscience (2006)
Grants and fellowships
H.Sjövall, M.Simrén , J.Bornstein, E.Thomas, M.Forsman. Integration
between intestinal motility and secretion Swedish Scientific
Council. (2003-2005) $545000.
E.Thomas. Dynamics of slow synaptic transmission University of
Melbourne early career researcher award. (2003) $38846.
E.Thomas. Analysis of mouse models of human familial epilepsies,
NHMRC Peter Doherty Fellowship. (2004-2007) $240000
Erdös number: 3